منابع مشابه
Autophagy: Starved β‐cells seem different from starved body
Macroautophagy (hereafter referred as “autophagy”) is a process where cellular components are sequestered into a vesicle (autophagosome) and are then degraded by lysosomal enzymes through formation of a fused vesicle (autolysosome). “Constitutive” autophagy was recently shown to have a role in maintaining mass and function of pancreatic islet b-cells. Additionally, dysregulated autophagy in b-c...
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Natural killer (NK) cells play a crucial role in regulating immune functions. Few studies have characterized canine NK cells. We previously demonstrated that canine peripheral blood lymphocytes (PBLs) with a low surface CD5 density (CD5lo) are considered a critical NK population. Natural killer cells in most mammals do not express T-cell markers, but canine CD5lo cells express surface molecules...
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Background: Umbilical cord blood (UCB) is an alternative source of hematopoietic stem cell transplantation (HSCT), used in Leukemia treatment. CD26+ cells, a fraction of CD34 positive cells, are a major population of UCB cells which negatively regulate the in vivo homing and engraftment of HSCs. CD26 is highly expressed in various cells such as HSCs, immune cells, fibroblasts, and epithelial ce...
متن کاملNK Cells and Trophoblasts
In placental mammals, viviparity--the production of living young within the mother's body--evolved under the auspices of the immune system. Elements of immunity were incorporated, giving pregnancy a mildly inflammatory character. Formation of the placenta, the organ that feeds the fetus, involves a cooperation between maternal natural killer (NK) cells and fetal trophoblast cells that remodels ...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2018
ISSN: 1529-2908,1529-2916
DOI: 10.1038/s41590-018-0197-9